Natural Products Chemistry & Research

ISSN - 2329-6836

Onyegbule FA

Faculty of Pharmaceutical Sciences, Department of Pharmaceutical & Medicinal Chemistry, NnamdiAzikiwe University, Nigeria

Publications
  • Research Article   
    Standardization and Antimalarial Evaluation of Crude Methanol and Endophytic Fungiextracts of Azadirachtaindica Leaves
    Author(s): Nwankwo Ogechukwulucy*, Okoye FBC and Onyegbule FA

    Background & objectives: Endophytes are capable of synthesizing bioactive compounds responsible for plants defense against pathogens, thus the evaluation of Azadirachtaindica antimalarial potential. Methods: Extraction,phytochemical and physicochemical evaluation of the powdered leaves of Azadirachtaindicawas done using standard methods. Isolation of the endophytic fungi was done using malt extract agar (5 days). Fungal fermentation was done (21 days) and ethyl acetate extracted. Acute toxicity tests were performed on the crude and endophytic fungal extracts. Antimalarial curative study was done for both extracts, with artemeter-lumefantrine as positive control to evaluate the percentage curative effect (PCE). HPLC analysis was based on the retention time and UV absorption spectra. Results: Phytoc.. Read More»

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