Cardiovascular and Metabolic Diseases, Crown Bioscience, Inc., Taicang, Jiangsu Province, People's Republic of China
Research Article
Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part V. Diabetic Nephropathy and Effects of Angiotensin Ⅱ Receptor Antagonist
Losartan
Author(s): Jiajun Gao, Xiaoli Wang, Weihua Song, Yixin (Jim) Wang and Yong-Fu Xiao*
Long-term hyperglycemia can impair renal microvessels and lead to diabetic nephropathy (DN). Early treatment can delay or prevent its progression. Efficacy of monoclonal antibody (mAb) therapies for human diseases can often be tested only in nonhuman primates (NHPs) but no other species due to lack of human mAb cross-reactivity. To test if DN in NHPs is similar to the human disease, this study analyzed the blood and urine biochemistry data from a large pool (n=129) of cynomolgus monkeys (Macacafascicularis). Compared with the normoglycemic monkeys, the diabetic animals were significantly aged and showed significantly higher levels of blood glucose, HbA1c, TC, TG, LDL and ALT. DN monkeys (n=47) significantly increased urine (24h) volume, glucose, albumin, total protein, bilirubin and albumin/creatinine ratio (ACR). The data showed significant correlations between age and 24h-urine gluc.. View More»
DOI:
10.35248/2155-6156.21.12.861
