Cardiovascular and Metabolic Diseases, Crown Bioscience Inc., Taicang, Jiangsu Province, People's Republic of China
Research Article
Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part IV. Pancreatic Beta Cell Dysfunction and Diabetes Progression
Author(s): Yong-Fu Xiao* and Yixin (Jim) Wang
Diabetes mellitus, hyperglycemia and polyuria, results from the body either producing insufficient insulin or using the produced insulin inefficiently to metabolize glucose. Type I diabetes mellitus (T1DM) is recognized as reduction of beta-cell mass mostly due to autoimmune destruction. However, insulin resistance and beta-cell dysfunction or loss are potentially the main causes of Type II diabetes mellitus (T2DM). Due to long-term hyperglycemia and microvascular impairment, complications are common, including heart, kidney, liver and other organs. Therefore, diabetic patients have the overall high risk of dying prematurely by heart attack, stroke, liver dysfunction and kidney failure. Diabetes has become one of the major global threats to human health. Development of safe and potent therapeutics is thus urgently needed. Animal models remain irreplaceable for discovering, validating .. View More»
DOI:
10.35248/2155-6156.19.10.832
