Hiroshi Ikeno, Takashi Kita and Shahram Mesri
Scientific Tracks Abstracts: Anaplastology
Sodium L-ascorbyl-2-phosphate (APS) is a derivative of vitamin C and works as a powerful scavenger of active oxygen species. One of the pathophysiologic factors in acne is an oxidization of fatty acid and squalene. APS is very effective in suppressing this oxidization. We have reported the efficacy of 5% APS lotion in the treatment of acne vulgaris since 2003. We also reported the efficacy of the combined therapy of 5%APS lotion and 0.1% AD gel in comparison with each monotherapy. This time, we report the clinical efficacy and safety of the combined topical therapy (5% APS and 0.3% AD gel) by comparing it with each one as monotherapy in the treatment of acne vulgaris. In a randomized, multicenter, open label, parallel study, ninety patients with facial acne were divided and assigned to receive 5% APS lotion plus 0.3% AD gel (APS+AD) (n=30), 5% APS lotion (APS) (n=30), and 0.3% AD gel (AD) (n=30), with twice-daily treatment. Evaluations of efficacy and safety were performed at basement, months 1, 3, and 6 by a blinded evaluator. Patients were instructed to refrain from receiving any other treatments or drugs for acne for 4 weeks prior to enrollment in the study. The number of patients who complied with the treatment protocol was 29 on APS+AD, 30 on APS, and 25 on AD. The number of patients, evaluated as good and excellent at 6 months of treatment, was 25/29 on APS+AD, 21/30 on APS, and 16/25 on AD. No serious adverse events were reported in any group. The efficacy rate for APS+AD, APS, and AD was 86.2%, 70.0% and 64.0% respectively. The efficacy of APS+AD was superior to APS, and AD alone. It can be concluded that combination therapy with APS+0.3AD is more effective than APS or 0.3AD monotherapy, which is widely prescribed in western countries for the treatment of acne vulgaris.
Hiroshi Ikeno has completed his MD at the age of 28 years from Mie University in 1984 and postdoctoral studies from Osaka University School of Medicine in1989 and from Tokyo Medical & Dental University School of Medicine in 1992, serving as the dermatological director of some public hospitals in Japan. He is the director of Ikeno Clinic of Dermatology and Dermatological surgery. He has published more than 10 papers in dermatological journals in Europe and USA, serving as a reviewer board member of journals, which impact factors are high.