Malaria is an endemic infectious illness that causes morbidity and mortality in tropical and sub-tropical places around the world. Detarium microcarpum (Fabaceae) has long been used to treat malaria, diabetes, hypertension, pneumonia, and other ailments. The goal of this study is to see how effective antiplasmodial drugs are and how safe they are. Detarium microcarpum leaf extract in methanol Oral median lethal dosage (LD50) estimate and phytochemical screening. The extraction was completed. The antiplasmodial activity was tested in mice infected with chloroquine-resistant plasmodium. Curative, suppressive, and prophylactic experimental models for Plasmodium berghei-berghei Rats were fed rat food. Biochemical assay and hematological analysis were performed after administering the extract of Detarium microcarpum daily for 28 days. ANOVA was used to analyse the data, followed by Dunnett's post hoc test. Alkaloids, flavonoids, saponins, tannins, triterpenes, and glycosides were discovered by phytochemical analysis. The extract's oral LD50 was determined to be > 5000 mg/kg. The extract had substantial curative, suppressive, and preventive effects at all doses tested (p0.001). In comparison to the negative control group, the extract dramatically increased the survival period of the treated mice by 19 days. At the maximum dose, the extract caused a significant change in AST (p0.01) and ALP (p0.001). However, as compared to the control, no significant differences in renal function tests or hematological analyses were seen in any of the treatment groups. The findings of this study suggest that Detarium microcarpum methanol leaf extract has curative, suppressive, and preventive antiplasmodial activity, and that short-term usage at the levels examined was rather safe.
