Nigella sativa L. (NS) seeds, known as black seed, is a traditional herbal medicine used in various diseases including, antimicrobial, immunomodulatory, gastro and hepatoprotictive , bronchodialator. This review aimed to assess the studies supporting the medicinal use of NS in covid-19 patients and to highlight future research priorities. Various medical databases were searched for the effects of NS and its active secondary metabolites in Anti-inflammatory and analgesic properties asthma inflammation and outcomes. There were several preclinical studies describing multiple effects of NS in animal or cellular models immunological disorder including eczema, bronchodilation, antihistaminic, anti-inflammatory, anti-leukotrienes and immunomodulatory effects. Furthermore, clinical studies showed improvements in different cytokines outcomes and laboratory parameters. In conclusion, NS could be therapeutically beneficial in control cytokine storm. Associate with COVID-19 infection which is accompanied by an aggressive inflammatory response with the release of a large amount of pro-inflammatory cytokines, but the evidence remains scanty and is often based on poorly characterized preparations. Accordingly, well-designed large clinical studies using chemically well characterized NS preparation are required.