npcr

Natural Products Chemistry & Research

ISSN - 2329-6836

Commentry - (2018) Volume 6, Issue 6

Carvacrol: An Excellent Natural Pest Control Agent

Ratnamala Bendre1, Suresh Bagul1 and Jamatsingh Rajput1,2*
1Department of Chemical Sciences, Kavayitri Bahinabai Chaudhari, North Maharashtra University, Jalgaon, Maharashtra, India
2Department of Life Sciences, Kavayitri Bahinabai Chaudhari, North Maharashtra University, Jalgaon-425001, Maharashtra, India
*Corresponding Author: Jamatsingh Rajput, Department of Life Sciences, Kavayitri Bahinabai Chaudhari, North Maharashtra University, Jalgaon-425001, Maharashtra, India, Tel: +91 9673232264 Email:

Abstract

Carvacrol is found especially in many angiospermic plants, also conjointly produced naturally by from Origanum vulgare, thyme, oil obtained from pepperwort, wild bergamot and essential oils isolated from some plants. It is having scientific value in the ayurveda, chinese medicine, western herbalism and modern sciences due to its biological and pharmacological activities. Besides, it plays a vital role in pest control. Present report emphasizes on carvacrol to exploit its pest management efficacy and potency.

Keywords: Essential oil; Phenolic monoterpenes; Larvicidal; Ovicidal

Introduction

Environmental issues are circumscribing the employment of traditional pesticides. Growing resistance of pests to present pesticides has given urgency to the look for better, safer compounds and safer delivery systems. the necessity to treat a lot of exactly has conjointly provided additional opportunities for the utilization of natural products [1]. Being tropical country India has a wealth of plants, that continues to be underutilized, apart from neem which is getting used from ancient time for inset management [2]. The rapid growth of information of natural products, with biological activities towards pests currently provides a choice for treatment and a basis for biorational approaches to the planning of pest management agents [3]. Significantly over the past twenty-five years, there has been abundant activity directed to chemical work on isolation and identification of a large array of biologically active natural products that in same means affects the behavior, development and replica of pests and the growth of weeds [4,5]. Natural pheromones, antifeedants, insects and plant growth regulators have found commercial application, equally artificial analogs supported the natural products and have caught wider market [6].

Carvacrol is a chemical compound found in numerous angiospermic plants and herbs [7]. Carvacrol is a natural phenol, containing ten carbon unit having IUPAC name 5-isopropyl-2- methylphenol and molecular formula C10H14O [8]. This molecule isomeric with thymol, is produced by Thymus, Thymbra, Coridothymus, Satureja, oreganum, and Lippia, pepperwort, Origanum vulgare and Wild bergamot [9]. Carvacrol is what provides oregano a slightly spicy flavor, is colorless, and includes a distinct heat odor. Carvacrol exhibits wonderful anti-microbial properties and makes it helpful within the production of cosmetics, food preservatives and for treating diseases [10]. The focus of this case report is to highlight the extensive effects of carvacrol on the various agricultural pest.

The effective functional group in carvacrol

The biological activities of carvacrol are believed to be related to the functional group. It is suggested that the activities of carvacrol dependent upon the position of the hydroxy functional group and molecular configuration instead of volatility and molecular size [11,12]. The most promising potential for exploitation of this molecule as pest management chemical lies in the synthesis of derivatives and analogs through simple synthetic procedures and through the establishment of structure-activity relationships. Throughout preliminary studies it had been discovered that with the knowledge of the essential functional group, a molecule with high activity and specificity can be designed [13,14]. Thus, systematic derivatization of carvacrol could prove it as both source and a model for new commercial pest management agents having a natural base in forthcoming time.

Mode of action of carvacrol in pest

Mode of action of carvacrol for various effects have not been determined but reports provide some clues for its possible specific mechanisms [15]. Carvacrol exhibits several types of biological activities in pests [16]. Carvacrol induce an immediate neurotoxicity and it is reported that hydrophobicity of compounds influences the penetration through the cuticle and piperonyl butoxide synergized the toxic effects [17]. Carvacrol also inhibits acetylcholinesterase. The acetylcholinesterase inhibitory effect of carvacrol was found to be ten time stronger than that exerted by its structural isomer thymol [18]. They act at the picrotoxinin site of the GABA (γ-aminobutyric acid) receptor-ionophore complex and as an antagonist of GABA, thus, inhibiting the chloride uptake into the neuron through the chloride channel. Substituted carvacrol have been seen to elicit lindane like GABA antagonistic effects. Carvacrol affects the sensory receptor of the insect in repellent activity [19].

No any harmful effect

There are no any known noxious effects of carvacrol, and it's been consumed by humans for many years suggesting that there's no toxic result [20]. Studies have conjointly shown that carvacrol is metabolized and excreted within twenty-four hours of consumption, which shows that there is little risk of its increase within the body to any potential harmful level [21].

Carvacrol in pest management

Natural phenols are having pest management strength against many agricultural as well as public health pests [22]. Carvacrol as insect-control agents is reported by Tsao et al. where carvacrol and their analogs have shown comparatively wide-ranging bioactivity against agricultural and public health insect pests [23]. Carvacrol has been reported to have expressively enhanced larvicidal [24], ovicidal [25], acute and fumigant [26] activities against insects [27]. Carvacrol ethers showed better insecticidal action. Some of them displayed insect growth and development activity against mosquito larvae [28]. Carvacryl ethers and esters have been synthesized and evaluated as antibacterial agents [29]. Our research group is working on simple modification of carvacrol towards bioactive derivatives from 15 years [30,31]. A part of research work on carvacrol is on ether and ester derivatives and comprises of evaluation of antifungal, antibacterial activities on plant pathogenic microorganisms as well as insecticidal activities against stored grain pests [32]. Carvacryl esters were found to be most active against plant pathogenic bacteria. Carvacryl acetate and carvacryl allyl ether exhibited similar antibacterial activity in comparison with standard streptomycin against A. radiobacter and P. solanacearum [27].

Future prospects

Integrated Pest Management (IPM) is changing the scenario of today’s pest management. Plant products are rising as a viable part of IPM. The growing awareness of pesticide safety and government regulative policies are increasing the opportunities for nontoxic or moderately virulent, safer, effective and environmentally friendly pest management agents. The future pest management programme for sustainable agriculture and public health emphasizes on botanicals, isolated potent plant products and their derivatives in addition to safer chemicals and biopesticides. Therefore, now a day’s natural products are rapidly gaining importance. Expansive analysis activities are occurring for derivatization of natural products isolated from essential oils of higher plants and one amongst them is carvacrol having promising pest management effectuality. Carvacrol may be structurally modified to convert it into the potent and eco-friendly pesticides for future pest management. Thus, derivatization of carvacrol, rendering them comparatively stable and more target specific molecules, may be a viable strategy towards a more biorational approach to pest management.

Conclusion

Carvacrol is a simple phytochemical component, showing potent biological activities. The potent pesticidal activities of carvacrol and its derivatives have, attracted a lot of attention recently. Studies have shown the efficacy of carvacrol against a number of different pests of different origin. These findings indicated a possible use of carvacrol as effective tool against a wide variety of agricultural pests. The promising numbers of the satisfying potential of carvacrol is encouraging and further investigations are needed to fully realize the potential of these derivatives in agricultural research.

Acknowledgments

We are thankful to all those authors for publishing their research on carvacrol.

References

  1. Atal CK, Kapur BM (1982) Cultivation and utilization of medicinal plants. Jammu-Tawi, India. Regional Research Laboratory, Council of Scientific and Industrial Research.
  2. Hedin PA (1991) Naturally occurring pest bioregulators. Washington, DC:American Chemical Society
  3. Prokopy R, Kogan M (2009) Integrated pest management. In Encyclopedia of Insects, pp: 523-528.
  4. Karuppuchamy P, Venugopal S (2016) Integrated pest management. In Ecofriendly Pest Management for Food Security, pp: 651-684.
  5. Bale JS, Van Lenteren JC, Bigler F (2008) Biological control and sustainable food production. Philosophical Transactions of the Royal Society of London B: Bio Sci 363: 761-776.
  6. Mohankumar S, Ramasubramanian T (2014) Role of genetically modified insect-resistant crops in IPM: agricultural, ecological and evolutionary implications. In Integrated Pest Manag, pp: 371-399.
  7. Rajput JD, Bagul SD, Tadavi S, Bendre RS (2016) Comparative anti-proliferative studies of natural phenolic monoterpenoids on human malignant tumour cells. Med Aromat Plants 5: 2167-2412
  8. Bagul SD, Rajput JD, Tadavi SK, Bendre RS (2017) Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives. Res Chem Inter 43: 2241-2252.
  9. Zade CM, Pete UD, Kadam MS, Bendre RS (2012) Development of Novel Insect Growth Regulators: Effect of 1-(Substitutedbenzoyl)-3-[(2′-Isopropyl-5′-Methylphenoxy) Acetamino] Thiourea and Urea Derivatives on Total Haemocyte Count of Dysdercus koenigii. In Chem Sustain Develop, pp: 69-79.
  10. Bagul SD, Rajput JD, Patil MM, Bendre RS (2017) Synthesis, Characterization and Antioxidant Activity of Carvacrol Based Sulfonates. Med Chem 7: 294-298.
  11. Suresh DB, Jamatsing DR, Pravin SK, Ratnamala SB (2016) Synthesis, characterization and antioxidant activity of carvacrol containing novel thiadiazole and oxadiazole moieties. Mod Chem Appl 4: 2.
  12. Rajput JD, Bagul SD, Bendre RS (2017) Design, synthesis, biological screenings and docking simulations of novel carvacrol and thymol derivatives containing acetohydrazone linkage. Res Chem Inter 43: 4893-4906.
  13. Rajput JD, Bagul SD, Tadavi SK, Karandikar PS, Bendre RS (2016) Design, synthesis and biological evaluation of novel class diindolyl methanes (DIMs) derived from naturally occurring phenolic monoterpenoids. Med Chem 6: 123-128.
  14. Rajput JD, Bagul SD, Bendre RS (2017) Synthesis, biological activities and molecular docking simulation of hydrazone scaffolds of carvacrol, thymol and eugenol. Res Chem Inter 43: 6601-6616.
  15. Harwood SH, Moldenke AF, Berry RE (1990) Toxicity of peppermint monoterpenes to the variegated cutworm (Lepidoptera: Noctuidae). J Eco Entomol 83: 1761-1767
  16. Nieto G (2017) Biological activities of three essential oils of the Lamiaceae family. Med 4: 63.
  17. Ryan MF, Byrne O (1988) Plant-insect coevolution and inhibition of acetylcholinesterase. Journal Chemical Ecology 14: 1965-1975.
  18. Jukic M, Politeo O, Maksimovic M, Milos M (2007) In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phyto Res 21: 259-261.
  19. Cole LM, Casida JE (1992) GABA-gated chloride channel: Binding site for 4′-ethynyl-4-n-[2, 3-3H2] propylbicycloorthobenzoate ([3H] EBOB) in vertebrate brain and insect head. Pest Biochem Physiol 44: 1-8.
  20. Suntres ZE, Coccimiglio J, Alipour M (2015) The bioactivity and toxicological actions of carvacrol. Critic Rev Food Sci Nutr 55: 304-318.
  21. Hagan EC, Hansen WH, Fitzhugh OG, Jenner PM, Jones WI (1967) Food flavourings and compounds of related structure. II. Subacute and chronic toxicity. Food Cosmetics Toxicol 5: 141-157
  22. Mossa ATH (2016) Green pesticides: Essential oils as biopesticides in insect-pest management. J Environ Sci Technol 9: 354.
  23. Tsao R, Coats JR (1995) Starting from nature to make better insecticides. Chemtech 25: 23-28.
  24. Giatropoulos A, Kimbaris A, Michaelakis Α, Papachristos DP, Polissiou MG (2018) Chemical composition and assessment of larvicidal and repellent capacity of 14 Lamiaceae essential oils against Aedes albopictus. Parasitol Res 117: 1953-1964.
  25. Muturi EJ, Ramirez JL, Zilkowski B, Flor-Weiler LB, Rooney AP (2018) Ovicidal and Larvicidal Effects of Garlic and Asafoetida Essential Oils Against West Nile Virus Vectors. J Insect Sci 18: 43.
  26. Rozman V, Kalinović I, Liška A (2006) Bioactivity of 1, 8-cineole, camphor and carvacrol against rusty grain beetle (Chryptolestes ferrugineus Steph.) on stored wheat. In 9th International Working Conference on Stored Product Protection.
  27. Park JH, Jeon YJ, Lee CH, Chung N, Lee HS (2017) Insecticidal toxicities of carvacrol and thymol derived from Thymus vulgaris Lin. against Pochazia shantungensis Chou and Lu, newly recorded pest. Sci Reports 7: 40902.
  28. Mathela CS, Singh KK, Gupta VK (2010) Synthesis and in vitro antibacterial activity of thymol and carvacrol derivatives. Acta Pol Pharm 67: 375-380.
  29. Dewang PM, Nikumbh VP, Tare VS, Mahulikar PP (2003) Eco-friendly Pest Management Using Monoterpenoids II-Antifungal Efficacy of Menthol Derivatives.
  30. Rajput JD, Bagul SD, Pete UD, Zade CM, Padhye SB (2018) Perspectives on medicinal properties of natural phenolic monoterpenoids and their hybrids. Mol Divers 22: 225-245.
  31. Bagul SD, Rajput JD, Srivastava C, Bendre RS (2018) Insect growth regulatory activity of carvacrol-based 1, 3, 4-thiadiazoles and 1, 3, 4-oxadiazoles. Mol Divers, 22: 1-9.
  32. More UB, Narkhede HP, Mahulikar PP (2008) Synthesis of new dimeric carvacrol compounds. Org Comm 1: 69.
Citation: Bendre R, Bagul S and Rajput J (2018) Carvacrol: An Excellent Natural Pest Control Agent. Nat Prod Chem Res 6: 349.

Copyright: © 2018 Bendre R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.