Natural Products Chemistry & Research

ISSN - 2329-6836


Acute Toxicity (LD50) Studies Using Swiss Albino Mice and Brine Shrimp Lethality (LC50 and LC90) Determination of the Ethanol Extract of Stem Bark of Echinaceae angustifolia DC.

Abdu Zakari and Dimas Kubmarawa

The ethanol extract of Echinaceae angustifolia DC was tested for acute toxicity (LD50) using Swiss Albino Mice and was screened for Brine Shrimp lethality using Artemia salina larvae. The results showed that the plant was toxic to the mice at even a lower concentration (300 mg/Kg) and caused death at a concentration of 500 mg/Kg body weight of the live mice. The LD50 was found to be 3,807.89 mg/Kg. The result of the Brine Shrimp lethality showed that the extract was toxic to the naupli with an LC50 and LC90 values of 125.89 μg/mL and 794.33 μg/mL respectively.