Natural Products Chemistry & Research

ISSN - 2329-6836


Mineral Salt Composition and Secondary Metabolites of Ocimum gratissimum L., An Anti-hyperglycemic Plant

N’Guessan Bra YF, Martin K, Kiyinlma C, Rokia S and Dieneba KB

Diabetes mellitus affects more and more people in poor areas of developing countries. The search for an adequate treatment and within the reach of the population has moved us to select the leaves of Ocimum gratissimum. Phytochemical screening was carried out on one hand, detecting major groups of secondary metabolites, on infused 10% aqueous and on the other hand minerals salt in point microanalysis dispersive spectrometry. Toxic test was carried out using white mice CF1 type. The phytochemical screening revealed the presence of saponin, sterol and terpenes, alkaloid polyphenols, tannins and flavonoids and especially mucilage. The amounts of total polyphenols and total flavonoids were respectively 11.98 mg EAG/g and 3.99 mg EQ/g of dry extract. The phytochemical screening revealed moisture content of 8.97%, total ash of 8.45%, sulfuric ash of 10.27% and ash insoluble in hydrochloric acid 0.96%. The presence of Cu, Zn, K, Ca and Mg having an important role in glucose metabolism was revealed. The study of acute toxicity showed that the toxic dose could be greater than 3000 mg/kg. Also, the leaves are eaten as human food by some people. The results of the studies indicated that the leaves of Ocimum gratissimum contains minerals and bioactive secondary metabolites that, in combination, may explain their therapeutic uses for treating diabetes mellitus.