Natural Products Chemistry & Research

ISSN - 2329-6836


Natural Product as a Source of Lead to the Design of New Drugs

Harshal Ashok Pawar

Natural products have been a source of medicinal agents since thousands of year and remarkable numbers of modern drugs have been derived from natural sources, predominantly based on their knowledge available in traditional medicine. The modern natural product research is undergoing a revolution due to recent advancements in combinatorial biosynthesis, microbial genomics and screening processes. The total synthesis of complex natural products has long presented a big challenge to the synthetic chemist, and led to considerable advances in synthetic methodology. To continue to be competitive with other drug discovery methods, natural product research needs to continually improve the speed of the screening, isolation, and structure elucidation processes, as well addressing the suitability of screens for natural product extracts and dealing with issues involved with large-scale compound supply.