Natural Products Chemistry & Research

ISSN - 2329-6836


Phytochemical, Anti-inflammatory and Analgesic Studies of the Crude Ethanolic Leaf Extract of Globimetular brounii Van Tieghem (Family: Loranthaceae)

Atiku I, Sule MI, Pateh UU, Musa AM, Ya’u J, Sani YM, Hanwa UA, Abdullahi SM, Adamu SA, Lawal EA and Abdulrahman H

Globimetula braunii is a bushy parasitic plant growing on Terminalia catappa, which has a variety of use in African traditional medicine. The leaves of the plant was subjected to preliminary phytochemical analysis, Acute Toxicity studies and analgesic activity using Hot plate and acetic acid induced pain method in mice, while the anti-inflammatory activity was tested using Carrageenan-induced paw oedema in rats. The Phytochemical analysis of the ethanolic leaf extract of Globimetula braunii revealed the presence of Carbohydrate, Steriods, Triterpenes, Tannins, Saponins, Alkaloids and Flavonoids; The LD50 was found to be greater than 5000 mg/kg which shows that the plant extract is relatively safe. The results from the Hot-plate method showed that the extract was statistically significant at (p<0.02 and p<0.01), this shows that there is increase in the latency of pain in the extract compare to standard drug pentazocine (20 mg/kg), while the Acetic acid induced method the extract was statistically significant at (p<0.02) with a percentage of inhibition of 65.5%, 65.2%, and 67.7% at the doses of 12.5 mg/kg, 25 mg/kg, and 50 mg/kg compared with the standard drug piroxicam (10 mg/kg) with a percentage inhibition of 54.3%. The extract was also found to significantly (P<0.05) inhibit oedema at all doses: 250 mg/kg, 500 mg/kg and 1000 mg/kg. This shows that the plant contains phytochemical constituent with analgesic and anti-inflammatory activities.