Natural Products Chemistry & Research

ISSN - 2329-6836

Chiharu Kawakami

  • Research Article
    Potential Anti-Influenza Virus Agents Based on Coffee Ingredients and Natural Flavonols
    Author(s): Kunihiro Kaihatsu, Chiharu Kawakami and Nobuo KatoKunihiro Kaihatsu, Chiharu Kawakami and Nobuo Kato

    Natural phenolic compounds have been reported to directly inhibit influenza virus. Nonetheless, there have been no reports on the direct inhibitory effects of coffee ingredients. Here, we fractionated the hydrophobic and hydrophilic components of coffee. The hydrophobic fraction directly inhibited both a seasonal influenza A/Puerto Rico/8/24(H1N1) virus and a neuraminidase-resistant influenza A/Yokohama/77/2008(H1N1) virus infection in a dosedependent manner, while the hydrophilic fraction did not show any inhibitory effects, even at concentrations above 100 μg/ml. The HPLC profile of the hydrophobic fraction indicated that caffeine is the major component. Indeed, caffeine alone showed comparable anti-influenza virus activity. Interestingly, caffeic acid also inhibited viral infection, while chlorogenic acid, which is an ester of caffeic acid and (-)-quinic acid, showed no obvious .. Read More»
    DOI: 10.4172/2329-6836.1000129

    Abstract PDF

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