Natural Products Chemistry & Research

ISSN - 2329-6836

An efficient synthesis of a bioactive benzenoid derivative from the mycelium of Antrodia camphorate and its anti-viral activity

5th International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products

July 24-25, 2017 Melbourne, Australia

Shu-Han Yang, Jyuan-Siou Lin, Shu-Hao Lee, Chang-Jer Wu and Ching-Kuo Lee

Power Nature Company, Taiwan
Taipei Medical University, Taiwan
National Taiwan Ocean University, Taiwan

Posters & Accepted Abstracts: Nat Prod Chem Res

Abstract :

Antrodia Camphorata (AC), a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for the treatment of liver-related cancer and inflammation syndromes. Compound S3 was isolated from the mycelium of AC. In this study we found that S3 displayed potent anti-influenza A virus activity. Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) in 2009. Now the influenza A (H1N1) treatment is done by Tamiflu®. However, Tamiflu® has a lot of side effects, for example users may have mental illness symptoms. The cytotoxicity evaluation of S3 against baby hamster kidney cell lines (BHK-21) showed that S3 was slightly higher active than Tamiflu® (cell viability still has more than 80%), but S3 treatment effect better than Tamiflu®. In addition, the animals have no adverse effects after long-term use S3. It was a potent inhibitor of influenza A (H1N1) virus, with higher activity than the reference compound Tamiflu®. However, the content of S3 is rarely found in the mycelium of AC. Synthesia of the key chemical S3 compound in our laboratory was done through the AlCl3 followed by demethylation. The yield was 23% in one step. This paper offers the first report of the anti-influenza A virus activity by S3. Moreover the key benzenoid component S3 was prepared only in one step.

Biography :

Shu-Han Yang has completed her Master’s degree from National Taiwan Normal University. She is an Assistant Researcher at Research and Development Department of Power Nature Company and School of Pharmacy of Taipei Medical University. She has published 1 paper in reputed journal.

Email: [email protected]