Shu-Han Yang, Jyuan-Siou Lin, Shu-Hao Lee, Chang-Jer Wu and Ching-Kuo Lee
Power Nature Company, Taiwan
Taipei Medical University, Taiwan
National Taiwan Ocean University, Taiwan
Posters & Accepted Abstracts: Nat Prod Chem Res
Antrodia Camphorata (AC), a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for the treatment of liver-related cancer and inflammation syndromes. Compound S3 was isolated from the mycelium of AC. In this study we found that S3 displayed potent anti-influenza A virus activity. Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) in 2009. Now the influenza A (H1N1) treatment is done by Tamiflu®. However, Tamiflu® has a lot of side effects, for example users may have mental illness symptoms. The cytotoxicity evaluation of S3 against baby hamster kidney cell lines (BHK-21) showed that S3 was slightly higher active than Tamiflu® (cell viability still has more than 80%), but S3 treatment effect better than Tamiflu®. In addition, the animals have no adverse effects after long-term use S3. It was a potent inhibitor of influenza A (H1N1) virus, with higher activity than the reference compound Tamiflu®. However, the content of S3 is rarely found in the mycelium of AC. Synthesia of the key chemical S3 compound in our laboratory was done through the AlCl3 followed by demethylation. The yield was 23% in one step. This paper offers the first report of the anti-influenza A virus activity by S3. Moreover the key benzenoid component S3 was prepared only in one step.
Shu-Han Yang has completed her Master’s degree from National Taiwan Normal University. She is an Assistant Researcher at Research and Development Department of Power Nature Company and School of Pharmacy of Taipei Medical University. She has published 1 paper in reputed journal.
Email: a78322003@hotmail.com
