Afaf Al Groshi, Lutfun Nahar, Andrew Evans, Abdurazag Auzi, Satyajit D Sarker and Fyaz M D Ismail
UK
Posters & Accepted Abstracts: Nat Prod Chem Res
n-Hexane, dichloromethane and MeOH extracts of the leaves and tubers of Asphodelus aestivus were screened for their cytotoxicity against two human cancer cell lines, namely, lung (A549) and prostate (PC3) using the in vitro MTT assay. Significant cytotoxicity was observed with A. aestivus tubers against both cell lines, whereas, the dichloromethane extract of A. aestivus leaves showed activity only against the lung (A549) cell lines with the IC50 value of 90 μg/mL. The n-hexane and the dichloromethane extracts of tubers exhibited relatively high level of cytotoxicity against the prostate cancer cells (PC3) with the IC50 values of 80 and 19 μg/mL, respectively. The dichloromethane extract of the tubers also showed considerable cytotoxicity against the lung (A549) cancer cells (IC50 value of 16 μg/mL). The selectivity index (SI) for A. aestivus tubers was also determined using the human normal prostate cell line (PNT2). The tubers revealed high degree of cytotoxic selectivity on prostate cancer cells (SI=26).
Afaf Al Groshi has her expertise in pharmacognosy, phytochemistry, natural products and in vitro cytotoxicity study. She has built this work after years of experience in research, evaluation, teaching and administration in education institutions.
Email: afaf.gerushi@gmail.com
