Alok Kumar Pandey, Priya Singh, Swati Rathore, Prashant Sahu and Sushil Kumar Kashaw
Dr H S Gour Central University, India
Posters-Accepted Abstracts: Nat Prod Chem Res
Head and Neck Squamous Cell Carcinoma (HNSCC) is reported to be the 8th leading cause of cancer death worldwide but a safe, convenient and effective treatment is still challenging for researchers. So far, treatment for HNSCC is limited to various surgical strategies. These therapies possess the disadvantage of being painful, harmful and costly, thus have little patient compliance, obligating the need of a safer, effective and compliant therapy. Nanogels can be used effectively to entrap various anti-HNSCC approved anticancer drugs for their topical delivery to cancerous squamous cells of skin of head, neck and various other regions. Nanogel being biocompatible, biodegradable and having high drug loading capability can prove to be a good carrier for various anticancer agents with easier administration and lesser side effects. Major problems which may arise against efficient drug delivery can be the level of drug penetration through skin and the specific release of the drug in the carcinoma cells. Skin penetration is itself enhanced by nanocarriers. Further, penetration enhancers and other physical methods may be utilized. Specificity of the drug delivery to target cells can be achieved by using pH based nanogel formulations. Thus, nanogels can prove to be very efficient formulation for tropical treatment of HNSCC and also other skin cancers.
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