Ogbonna John Dike N, Nwobi Chinekwu S and Attama Anthony A
University of Nigeria, Nigeria
Posters-Accepted Abstracts: Nat Prod Chem Res
Solid lipid microparticles (SLMs) which are recent drug delivery system employed in the delivery of drugs in addition of having advantages of lipid formulations are biocompatible, less toxic, long term stability etc. In this study, lipid was extracted from the goat fat using wet rendering method. The lipid matrix was prepared by fusion method and the drug loaded (chloroquine phosphate, halofantrine and artemether/lumefantrine) SLMs formulated by hot homogenization. The in vivo activity of the SLMs on Plasmodium berghei infected mice was done using Peter�??s four day suppressive protocol and the histological studies performed after the mice were sacrificed. The SLMs were stable. The SLMs containing arthemeter/lumefantrine had 87.01% parasite clearance while the commercial formulation of arthemeter/lumefantine had 80.0% parasite clearance; SLMs containing chloroquine phosphate had 87.10% parasite clearance while the commercial formulation of chloroquine phosphate had 84.12% parasite clearance; SLMs containing halofantrine had 72.96% parasite clearance while the commercial formulation of halofantrine had 85.71% parasite clearance. The group G which received no treatment had 14.89% parasite clearance. The SLMs formulations had good in vivo activity compared to the commercial formulation and were not harmful to the vital organs of the mice therefore SLMs can be an alternative means of formulating these antimalarials.
Email: john.ogbonna@unn.edu.ng
