The presence of cryoglobulins in the serum distinguishes cryoglobulinemia from other diseases. The makeup of cryoglobulins varies, which affects the clinical presentation and the underlying illness that causes cryoglobulin production. Type I cryoglobulinemia is present only in clonal hematologic illnesses, whereas type II/III cryoglobulinemia, also known as mixed cryoglobulinemia, is seen in hepatitis C virus infection and systemic diseases such as B-cell lineage hematologic malignancies and connective tissue disorders. Arthralgia, purpura, skin ulcers, glomerulonephritis, and peripheral neuropathy are just a few of the symptoms that might appear. Only a small percentage of individuals will develop life-threatening symptoms.
