Journal of Kidney

ISSN - 2472-1220


Interactions of EGFR and the Hippo Pathway in Diabetic Nephropathy

Chen J and Harris RC

Diabetic nephropathy (DN) is one of the most important complications of diabetes mellitus (DM), and it continues to rank as the leading cause of end-stage renal disease (ESRD) in the U.S. In our recently published manuscript, both in vitro and in vivo data showed that in response to high glucose, YAP expression and activation in renal proximal tubule epithelial cells were upregulated through activation of an EGFR- PI3K-Akt-CREB dependent pathway and subsequent activation of CTGF and AREG gene expression. The existence of crosstalk between EGFR and Hippo signaling pathway in diabetic kidney indicates the Hippo pathway may serve as an alternative novel therapeutic target of DN treatment.