Danguilan RA
Philippines
Research Article
Outcome of Adults with Leptospirosis and Renal Failure Treated with Pulse Immunosuppression
Author(s): Pasamba EM, Arakama MI, Danguilan RA and Mendoza MTPasamba EM, Arakama MI, Danguilan RA and Mendoza MT
Introduction: Leptospirosis presenting with renal failure is often accompanied by pulmonary hemorrhage and carries a high mortality despite standard therapy. There is increasing evidence for an immunologic mechanism mediating both these complications hence methylprednisolone and cyclophosphamide were adapted in the treatment protocol to improve overall outcome.
Methods: This is a retrospective review of adults with leptospirosis and renal failure admitted at National Kidney and Transplant Institute from January 2014 to December 2016 treated with pulse immunosuppression followed up until hospital discharge. Primary outcome is overall survival while secondary outcomes include predictors of mortality, length of hospital stay, number of days on hemodialysis, use of blood products and occurrence of nosocomial infection.
Results:.. View More»
