Hirofumi Jono
Japan
Research Article
Effect of Administration Duration of Low Dose Methotrexate on Development of Acute Kidney Injury in Rats
Author(s): Xiao Li, Erika Abe, Yukako Yamakawa, Go Yoneda, Rika Fujino, Mami Yamashita, Yuumi Iida, Hirofumi Jono and Hideyuki SaitoXiao Li, Erika Abe, Yukako Yamakawa, Go Yoneda, Rika Fujino, Mami Yamashita, Yuumi Iida, Hirofumi Jono and Hideyuki Saito
Methotrexate (MTX) is currently utilized as a key drug in treatment of both malignant tumors and rheumatoid arthritis. However, MTX treatment is often associated with various side effects, such as pulmonary damage, hepatotoxicityand nephrotoxicity. Recent report also revealed that, even though total administered dosage of MTX was same, longer duration of MTX administration caused more severe adverse effect rather than short duration of its administration in clinical. Despite the importance of appropriate usage of MTX, the mechanism of kidney injury caused by the difference in duration of MTX administration remains still unknown. Here, we established animal models to determine the effect of administration duration on MTX-induced kidney injury and evaluated the significant factor and mechanism responsible for MTX caused-kidney injury. The dosage of MTX .. View More»
