Journal of Kidney

ISSN - 2472-1220

Harris RC

Harris RC


  • Short Communication
    Interactions of EGFR and the Hippo Pathway in Diabetic Nephropathy
    Author(s): Chen J and Harris RCChen J and Harris RC

    Diabetic nephropathy (DN) is one of the most important complications of diabetes mellitus (DM), and it continues to rank as the leading cause of end-stage renal disease (ESRD) in the U.S. In our recently published manuscript, both in vitro and in vivo data showed that in response to high glucose, YAP expression and activation in renal proximal tubule epithelial cells were upregulated through activation of an EGFR- PI3K-Akt-CREB dependent pathway and subsequent activation of CTGF and AREG gene expression. The existence of crosstalk between EGFR and Hippo signaling pathway in diabetic kidney indicates the Hippo pathway may serve as an alternative novel therapeutic target of DN treatment. .. View More»

    DOI: 10.4172/2472-1220.1000105

    Abstract PDF

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